Three B vitamins together help to lower Homocysteine levels decreasing the risk of cardiovascular damage. Which combination is listed as correct?

• A. B1 and B2 Only
• B. B6, B7, and B12
• C. B1, B3, and B12
• D. B6, B12 and Folic Acid

Answer: (D)

Lowering homocysteine relies on B vitamins acting as cofactors in its metabolism. Homocysteine is recycled to methionine via a remethylation pathway that needs folate (as its active form) and vitamin B12, and it can also be degraded through a transsulfuration pathway that requires vitamin B6. Providing B6, B12, and folate supports both routes, helping to keep homocysteine levels down and potentially reducing cardiovascular risk. The combination that includes B6, B12, and folic acid matches these metabolic roles, whereas the other sets omit one of these critical cofactors or include vitamins not primarily involved in homocysteine metabolism.